Isolating the impact of tissue heterogeneities in high dose rate brachytherapy treatment of the breast

Isolating the impact of tissue heterogeneities in high dose rate brachytherapy treatment of the breast

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Background and purpose: Clinical brachytherapy treatment planning is performed assuming the patient is composed entirely of water and infinite in size.In this work, the effects of this assumption on calculated dose were investigated by comparing dose to water in water (Dw,w) in an unbound phantom mimicking TG-43 conditions, and dose to medium in medium (Dm,m) for breast cancer patients treated with high dose rate brachytherapy.Materials and methods: Treatment plans for 123 breast cancer patients were recalculated with here a Monte Carlo-based treatment planning software.

The dwell times and dwell positions were imported from the clinical treatment planning system.The dose was computed and reported as Dw,w and Dm,m.Dose-volume histogram (DVH) metrics were evaluated for target volumes and organs at risk.

Results: Dw,w overestimated the dose for most studied DVH metrics.The largest median overestimations between Dm,m and Dw,w were seen for the planning target volume (PTV) V200% (5.8%), lung D0.

1 cm3 (6.0%) and skin D0.1 cm3 (4.

2%).The differences between Dm,m and Dw,w were statistically klaire labs ashwagandha significant for all investigated DVH metrics.The PTV V90% had the smallest deviation (0.

7%).Conclusion: There was a significant difference in the DVH metrics studied when tissue heterogeneities and patient-specific scattering are accounted for in high dose rate breast brachytherapy.However, for the studied patient cohort, the clinical coverage goal (PTV V90%), had the smallest deviation.